fluoxetine and diclofenac interaction on food intake in goldfish, carassius auratus
نویسندگان
چکیده
this study was carried out to investigate the interaction of simultaneous use of fluoxetine (flx), a selective serotonin reuptake inhibitor, and diclofenac (dcf), a nonsteroidal anti-inflammatory drug, on food intake in goldfish, carassius auratus . treatments with different dosage of flx including control, 0, 1, and 10 µg/g body weight (bw) were injected in the fish with mean weight of 30.16 ± 8.57 g every other day in total of 5 times. then fish were exposed to 3 different levels of dcf including 0, 10, and 100 mg/l for 5 days. injection of fluoxetine significantly decreased food intake and consequently body weight. after 5 days exposure to dcf, the amount of food intake in the dcf receiving treatments of 1 mg/l and 10 mg/l was significantly larger than that of 0 mg/l dcf recieving treatment in both the flx dosage groups of 1 μg/g bw and 10 μg/g bw. our results indicated that dcf inhibits behavioral change effects of flx showing the complex effects of pharmaceuticals on fish.
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عنوان ژورنال:
international journal of aquatic biologyجلد ۲، شماره ۴، صفحات ۱۷۲-۰
کلمات کلیدی
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